Trifluoroacetic Acid (TFA) Market: Overview
Trifluoroacetic acid (TFA) is the simplest perfluoroorganic acid available. It is characterized by its strong acidity, high dielectric constant, miscibility with water and most organic solvents, and relativity low boiling point (71.8°C). Using highly acidic compounds in an organic synthesis allows better manipulations of end-products in a reaction. It is perhaps one of the most widely used fine chemicals in the world. Trifluoroacetic acid is prepared through the electrochemical fluorination of acetyl chloride or acetic anhydride in anhydrous hydrogen fluoride using the Simons process. This is followed by the hydrolysis of the resulting trifluoroacetyl fluoride in excellent yields (>90%). In 1922, Frédéric Swarts, a Belgian chemist, first discovered the trifluoroacetic acid reagent. It is widely employed in organic synthesis as a solvent or as an acid catalyst for different organic transformations such as solvolysis, rearrangements, functional group deprotections, oxidations, reductions, condensations, and hydroarylations as well as in trifluoromethylation reactions.
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Trifluoroacetic Acid (TFA) Market: Trends & Developments
The trifluoroacetic acid (TFA) market is anticipated to expand at a robust pace owing to the low cost, high acidity, easy elimination, and high solubility in water and organic solvents of trifluoroacetic acid (TFA), which makes it a catalyst of choice for a variety of reactions. The most frequent use of trifluoroacetic acid (TFA) is in organic synthesis. Its wide usage in the pharmaceutical and agricultural industry is anticipated to drive the market. Trifluoroacetic acid is not biodegradable and is somewhat toxic to aquatic life. This raises environmental concerns while using it in the manufacturing sector. This is expected to act as a restraint for the trifluoroacetic acid (TFA) market during the forecast period.
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Trifluoroacetic Acid (TFA) Market: Key Segments
In terms of application, the trifluoroacetic acid (TFA) market can be segmented into solvents, rearrangements, protecting group removal, oxidations, reductions, condensations, reactions with organophosphorus reagents, hydroarylations, synthesis of trifluoromethyl building blocks and trifluoromethyl substituted compounds and others. The others segment includes iodination and metal mediated reactions. Relatively recent applications of trifluoroacetic acid (TFA) in metal mediated reactions have proved its efficacy as a good ligand in organometallic chemistry.
Based on end-use industry, the trifluoroacetic acid (TFA) market can be segmented into pharmaceutical industry, agricultural industry, others. Trifluoroacetic acid (TFA) is used in CF3 substitution in organic compounds for many applications, particularly in biologically active compounds such as marketed pharmaceuticals mefloquine, fluoxetine, celecoxib, tipranavir, and efavirenz.
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Trifluoroacetic Acid (TFA) Market: Key Players
Key players operating in trifluoroacetic acid (TFA) market are Solvay, SRF Limited, TCI Chemicals, Shandong Xingfu New Material Co., Ltd., Nantong Baokai Chemical Co., Ltd., Halocarbon Products Corporation, and others.